Publications

Burger N, Mittenbühler MJ, Xiao H, Shin S, Wei SM, Henze EK, Schindler S, Mehravar S, Wood DM, Petrocelli JJ, Sun Y, Sprenger HG, Muro PL, Smythers AL, Bozi LHM, Darabedian N, Zhu Y, Seo HS, Dhe-Paganon S, Che J, Chouchani ET. The zinc-binding human cysteine proteome. Cell. 2025; 188:832-850.e27. 

Xiao H*†, Ordonez M*, Fink EC*, Covington TA, Woldemichael HB, Chen J, Jain MS, Rohatgi MH, Wei SM, Burger N, Sharif MA, Jan J, Wang Y, Petrocelli JJ, Blackmore K, Smythers AL, Zhang B, Gilbert M, Cheong H, Khetarpal SA, Smith A, Bogoslavski D, Lei Y, Vaites LP, McAllister FE, Van Bruggen N, Donovan KA, Huttlin ED, Mills EL, Fischer ES, Chouchani ET†. Covariation MS uncovers a protein that controls cysteine catabolism. Nature. 2025. († Corresponding authors | * authors contributed equally)

Sprenger HG*, Mittenbühler MJ*, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Smythers AL, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Paulo JA, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM. Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST. Cell Metabolism. 2025; 37:857-869.e9. (* authors contributed equally)

Chang RB, Toyoda HC, Hobbs SJ, Hadary R, Richmond-Buccola D, Wein T, Osterman I, Burger N, Chouchani ET, Sorek R, Kranzusch PJ. A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense. Molecular Cell. 2025; 85:3151-3165.e6.

Burger N† & Chouchani ET†. A new era of cysteine proteomics – Technological advances in thiol biology. Current Opinion in Chemical Biology. 2024; 79:102435. († Corresponding authors)

Shin YC*, Latorre-Muro P*, Djurabekova A, Zdorevskyi O, Bennett CF, Burger N, Song K, Xu C, Paulo JA, Gygi SP, Sharma V, Liao M, Puigserver P. Structural basis of respiratory complexes adaptation to cold temperatures. Cell. 2024; 187:6584-6598.e17. (* authors contributed equally) 

Liu W*, Wang Y*, Bozi LHM*, Fischer PD*, Jedrychowski MP, Xiao H, Wu T, Darabedian N, He X, Mills EL, Burger N, Shin S, Reddy A, Sprenger HG, Tran N, Winther S, Hinshaw SM, Shen J, Seo HS, Song K, Xu AZ, Sebastian L, Zhao JJ, Dhe-Paganon S, Che J, Gygi SP, Arthanari H, Chouchani ET. Lactate regulates cell cycle by remodelling the anaphase promoting complex. Nature. 2023; 616:790-797. (* authors contributed equally)

Mottahedin A, Prag HA, Dannhorn A, Mair R, Schmidt C, Yang M, Sorby-Adams A, Lee JJ, Burger N, Kulaveerasingam D, Huang MM, Pluchino S, Peruzzotti-Jametti L, Goodwin R, Frezza C, Murphy MP, Krieg T. Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke. Redox Biology. 2023; 59:102600.

Burger N, James AM, Mulvey JF, Hoogewijs K, Ding S, Fearnley IM, Loureiro-López M, Norman AAI, Arndt S, Mottahedin A, Sauchanka O, Hartley RC, Krieg T, Murphy MP. ND3 Cys39 in Complex I is Exposed During Mitochondrial Respiration. Cell Chemical Biology. 2022; 29:636–649.

Miljkovic JL, Burger N, Gawel JM, Mulvey JF, Norman AAI, Nishimura T, Tsujihata Y, Logan A, Sauchanka O, Caldwell ST, Morris JL, Prime TA, Warrington S, Prudent J, Bates GR, Aksentijević D, Prag HA, James AM, Krieg T, Hartley RC, Murphy MP. Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury. Redox Biology. 2022; 55:102429.

Wright JJ, Biner O, Chung I, Burger N, Bridges HR, Hirst J. Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System. Journal of the American Chemical Society. 2022; 144:6791-6801.

Gruszczyk AV, Casey AM, James AM, Prag HA, Burger N, Bates GR, Hall AR, Allen FM, Krieg T, Saeb-Parsy K, Murphy MP. Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury. Redox Biology. 2022; 54:102368.

Yin Z, Burger N, Kula-Alwar D, Aksentijević D, Bridges HR, Prag HA, Grba DN, Viscomi C, James AM, Mottahedin A, Krieg T, Murphy MP, Hirst J. Structural basis for a complex I mutation that blocks pathological ROS production. Nature Communications. 2021; 12:707

Ryan DG, Yang M, Prag HA, Blanco GR, Nikitopoulou E, Segarra-Mondejar M, Powell CA, Young T, Burger N, Miljkovic JLj, Minczuk M, Murphy MP, von Kriegsheim A, Frezza C. Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism. eLife. 2021; 10:e72593.

Burger N, Logan A, Prime TA, Mottahedin A, Caldwell ST, Krieg T, Hartley RC, James AM, Murphy MP. A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo. Free Radicals in Biology and Medicine. 2020; 147:37–47.

Prag HA, Kula-Alwar D, Beach TE, Gruszczyk AV, Burger N, Murphy MP. (2020). Mitochondrial ROS production during ischemia-reperfusion injury. In Oxidative Stress, pages 513–538. Elsevier.

Kohlhauer M*, Pell VR*, Burger N, Spiroski A-M, Gruszczyk AV, Mulvey JF, Mottahedin A, Costa ASH, Frezza C, Ghaleh B, Murphy MP, Krieg T. Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive. Basic Research in Cardiology. 2019; 114,18. (* authors contributed equally)

Antonucci S*, Mulvey JF*, Burger N, Di Sante M, Hall AR, Hinchy EC, Caldwell ST, Gruszczyk AV, Deshwal S, Hartley RC, Kaludercic N, Murphy MP, Di Lisa F, Krieg T. . Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. Free Radical Biology and Medicine, 2019; 134:678–687. (* authors contributed equally)

Pell VR, Spiroski A-M, Mulvey JF, Burger N, Costa ASH, Logan A, Gruszczyk AV, Rosa T, James AM, Frezza C, Murphy MP, Krieg T. Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation. Journal of Molecular and Cellular Cardiology, 2018; 123:88–91.

Vögtle F-N*, Brändl B*, Larson A*, Pendziwiat M*, Friederich MW*, White SM, Basinger A, Kücükköse C, Muhle H, Jähn JA, Keminer O, Helbig KL, Delto CF, Myketin L, Mossmann D, Burger N, Miyake N, Burnett A, van Baalen A, Lovell MA, Matsumoto N, Walsh M, Yu H-C, Shinde DN, Stephani U, Van Hove JLK†, Müller F-J†, Helbig I†. Mutations in PMPCB encoding the catalytic subunit of the mitochondrial presequence protease cause neurodegeneration in early childhood. American Journal of Human Genetics. 2018; 102:557–573. (*,† authors contributed equally)

Taskin AA, Kücükköse C, Burger N, Mossmann D, Meisinger C, Vögtle F-N. The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing. Molecular Biology of the Cell. 2017; 28:997–1002.

Mossmann D*, Vögtle F-N*, Taskin AA, Teixeira PF, Ring J, Burkhart JM, Burger N, Pinho CM, Tadic J, Loreth D, Graff C, Metzger F, Sickmann A, Kretz O, Wiedemann N, Zahedi RP, Madeo F, Glaser E, Meisinger C. Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation. Cell Metabolism. 2014; 20:662–669. (* authors contributed equally)